The triptych consists of The Adoration of the Shepherds (central panel, 253 x 304 cm); Saints Margaret and Mary Magdalen with Maria Portinari (right wing, 253 x 141 cm); Saints Anthony and Thomas with Tommaso Portinari (left wing, 253 x 141 cm).

Painted at Brugges on the commission of Tommaso Portinari, who was Medicean agent in that city. It was subsequently sent to Florence and placed upon the high altar of Sant'Egidio.